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In che modo il CBD influisce sul metabolismo del THC attraverso gli enzimi del citocromo P450?

In che modo il CBD influisce sul metabolismo del THC attraverso gli enzimi del citocromo P450? Il CBD influenza il metabolismo del THC interagendo con gli enzimi del citocromo P450, in particolare CYP3A4 e CYP2C9, che sono coinvolti nella degradazione di entrambi i cannabinoidi. Il CBD può inibire l'attività di questi enzimi, portando a un ridotto metabolismo del THC. Ciò può comportare effetti prolungati o potenziati del THC, poiché rimane nel corpo più a lungo a concentrazioni più elevate. L'inibizione degli enzimi CYP450 può anche interferire con il metabolismo di altri farmaci che vengono processati dagli stessi enzimi, aumentandone potenzialmente i livelli sierici e gli effetti. Questa interazione richiede un'attenta considerazione quando si combinano THC e CBD con altri farmaci per evitare interazioni farmacologiche avverse.

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