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In che modo le diverse vie metaboliche, come la conversione del THC in 11-idrossi-THC nel fegato, aumentano o diminuiscono la psicoattività?

In che modo le diverse vie metaboliche, come la conversione del THC in 11-idrossi-THC nel fegato, aumentano o diminuiscono la psicoattività? Quando il THC viene consumato per via orale, subisce il metabolismo nel fegato, dove viene convertito in 11-idrossi-THC, un composto psicoattivo più potente. L'11-idrossi-THC si lega più fortemente ai recettori CB1, portando ad un effetto psicoattivo potenziato e più duraturo rispetto alla dose iniziale di THC. Questa conversione è responsabile degli effetti più forti e sedativi comunemente associati ai prodotti commestibili a base di cannabis. D'altra parte, quando il THC viene inalato, bypassa il fegato ed entra direttamente nel flusso sanguigno, determinando effetti più rapidi ma potenzialmente di più breve durata. La via metabolica influenza in modo significativo l’intensità e la durata delle esperienze psicoattive.

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