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How can cannabinoid patches be optimized for local, targeted delivery in regions such as the wrist or ankle where skin absorption is different?

How can cannabinoid patches be optimized for local, targeted delivery in regions such as the wrist or ankle where skin absorption is different? To optimize cannabinoid delivery in areas like the wrist or ankle, patches can be designed with formulations that account for local skin thickness, lipid content, and absorption rates. These areas tend to have thinner skin and varying moisture levels, which can affect how cannabinoids penetrate. Using thinner, more flexible patches with localized delivery systems, such as micro-needle arrays or higher cannabinoid concentrations in specific reservoirs, can enhance absorption. Additionally, incorporating permeation enhancers that target the skin’s specific characteristics in these areas will improve the effectiveness of the patch.

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