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How can the interaction between cannabinoids and the skin’s extracellular matrix enhance or hinder absorption through transdermal patches?

How can the interaction between cannabinoids and the skin’s extracellular matrix enhance or hinder absorption through transdermal patches? The interaction between cannabinoids and the skin's extracellular matrix (ECM) plays a key role in absorption, as the ECM acts as a barrier that cannabinoids must traverse to enter deeper skin layers. Cannabinoids that are lipophilic may more easily pass through the lipid-rich ECM, while hydrophilic cannabinoids may face greater resistance. The skin’s ECM can either enhance or hinder absorption depending on the cannabinoid's solubility, molecular size, and the formulation's ability to penetrate the ECM. Optimizing cannabinoid formulations to interact favorably with the ECM can enhance absorption and therapeutic effects.

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