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How do cannabinoids in transdermal patches interact with topical medications or creams applied simultaneously?

How do cannabinoids in transdermal patches interact with topical medications or creams applied simultaneously? Cannabinoids and topical medications may compete for skin absorption pathways, potentially altering bioavailability. Lipophilic cannabinoids can enhance permeability, increasing the absorption of co-applied compounds. However, interactions with active pharmaceutical ingredients could affect therapeutic outcomes and safety. Careful formulation and compatibility testing are necessary to ensure effective co-administration (Baswan et al., 2020).

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