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How does the skin's natural barrier function impact the permeability of cannabinoids in transdermal patches for different skin types?

How does the skin's natural barrier function impact the permeability of cannabinoids in transdermal patches for different skin types? The skin's natural barrier function, including its lipid composition and thickness, impacts the permeability of cannabinoids when applied via transdermal patches. In individuals with thicker, drier, or more compromised skin (e.g., eczema), cannabinoid absorption may be slower or less efficient. On the other hand, individuals with thinner or oilier skin may experience faster absorption. Tailoring patch formulations to address these variations, such as using skin penetration enhancers or adjusting cannabinoid concentrations, can optimize therapeutic effects across different skin types.

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