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How does the use of cannabinoid patches compare with oral methods in terms of peak plasma concentrations and therapeutic window?

How does the use of cannabinoid patches compare with oral methods in terms of peak plasma concentrations and therapeutic window? Cannabinoid patches provide more stable and sustained plasma concentrations compared to oral methods, which are subject to first-pass metabolism in the liver. The transdermal route allows cannabinoids to enter the bloodstream gradually, leading to a more consistent therapeutic effect. This steady release from patches can widen the therapeutic window and reduce the risk of dose fluctuations, which are common with oral CBD products. Oral administration may result in higher peak plasma concentrations but can cause more pronounced fluctuations in therapeutic effects, especially with irregular dosing.

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