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What are the best techniques to quantify the cannabinoid content in transdermal patches over time to ensure consistency in delivery?

What are the best techniques to quantify the cannabinoid content in transdermal patches over time to ensure consistency in delivery? High-performance liquid chromatography (HPLC) is one of the most accurate methods to quantify cannabinoid content in transdermal patches, offering precise measurements of cannabinoid concentration. Other techniques like gas chromatography (GC) or mass spectrometry (MS) can also be used to analyze cannabinoid profiles. To ensure consistent delivery, sampling of patches at various intervals during wear can monitor the release profile and identify any variations. These methods help maintain the quality and efficacy of the patch throughout its use.

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