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What role do surfactants play in enhancing cannabinoid delivery through transdermal patches?

What role do surfactants play in enhancing cannabinoid delivery through transdermal patches? Surfactants are crucial in enhancing cannabinoid delivery through transdermal patches by reducing surface tension and improving the solubility of cannabinoids. They can help cannabinoids dissolve more easily in the skin's lipid-rich environment, facilitating better penetration. Surfactants also disrupt the stratum corneum, enhancing the permeability of the skin and allowing for faster and more efficient absorption. By improving the contact between cannabinoids and the skin, surfactants help increase the bioavailability of cannabinoids delivered through patches.

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