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Yetişkinlerde nöroinflamatuar yolakları modüle etmede CBG'nin CBD'den farkı nedir?

Kuidas erineb CBG CBD-st neuropõletikuliste radade moduleerimisel täiskasvanutel? CBG (kannabigerool) erineb CBD-st neuropõletikuliste radade moduleerimise poolest, sihikule ja aktiveerides spetsiifiliselt CB2 retseptoreid, millel on kesknärvisüsteemi põletiku vähendamisel oluline roll. Kui CBD interakteerub peamiselt endokannabinoidsüsteemiga mitte-CB1/CB2 mehhanismide kaudu, on CBG toimed otsesemalt seotud immuunmodulatsiooniga. Mõlemad kannabinoidid pärsivad põletikueelseid tsütokiine, kuid on leitud, et CBG vähendab tõhusamalt mikrogliia aktivatsiooni. Need erinevused rõhutavad CBG potentsiaali tugevama põletikuvastase ainena neurodegeneratiivsete haiguste korral (Brierley et al., 2016).

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