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Kako CBN djeluje na TRP kanale u živčanom sustavu i kako to utječe na upravljanje boli?

Kako CBN djeluje na TRP kanale u živčanom sustavu i kako to utječe na upravljanje boli? CBN aktivira TRP kanale poput TRPV1, koji igraju ulogu u nocicepciji i termoregulaciji, pridonoseći njegovim analgetskim učincima. Ova interakcija pomaže smanjiti osjetljivost na bol i upalne reakcije, čineći CBN učinkovitim za liječenje kronične i neuropatske boli. Njegovo kombinirano djelovanje s modulacijom CB2 receptora poboljšava sveukupno ublažavanje boli. Ova svojstva čine ga vrijednim kandidatom za terapiju boli na bazi kanabinoida. Potrebna su daljnja istraživanja kako bi se definirale njegove specifične interakcije TRP kanala.

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