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Kako se THC i CBD razlikuju u svom utjecaju na serotonergičku neurotransmisiju?

Kako se THC i CBD razlikuju u svom utjecaju na serotonergičku neurotransmisiju? THC i CBD se značajno razlikuju u interakciji sa serotonergičkim sustavom. THC ima djelomični agonistički učinak na 5-HT2A receptore, što može pridonijeti njegovim psihoaktivnim učincima poput euforije i, u nekim slučajevima, anksioznosti. S druge strane, pokazalo se da CBD djeluje kao modulator 5-HT1A receptora, potičući anksiolitičke učinke i oslobađanje serotonina, što može smanjiti tjeskobu i poboljšati raspoloženje. Interakcija CBD-a sa serotoninskim receptorima pomaže u ublažavanju nekih negativnih učinaka THC-a, poput paranoje i tjeskobe. Dakle, THC povećava signaliziranje serotonina na načine koji mogu izazvati tjeskobu, dok CBD pojačava aktivnost serotonina na umirujući i stabilizirajući način. Ovi različiti učinci pridonose ukupnom psihoaktivnom profilu proizvoda od kanabisa.

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