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Koja je uloga CBN-a u liječenju boli i kakav je u usporedbi s tradicionalnim analgeticima? Cannabinol (CBN) se pojavio kao potencijalni analgetik s jedinstvenim svojstvima koja mogu ponuditi prednosti u kontroli boli. Dok tradicionalni analgetici prvenstveno ciljaju puteve boli kroz mehanizme kao što su aktivacija opioidnih receptora ili protuupalno djelovanje, CBN može djelovati drugačije modulirajući endokanabinoidni sustav i ispoljavajući protuupalne učinke. Preliminarna istraživanja pokazuju da CBN može pomoći u ublažavanju boli, osobito kod upalnih stanja, bez psihoaktivnih učinaka povezanih s THC-om. Međutim, potrebna su daljnja istraživanja za usporedbu učinkovitosti i sigurnosti CBN-a s tradicionalnim analgeticima, kao što su nesteroidni protuupalni lijekovi (NSAID) i opioidi, kako bi se utvrdila njegova uloga u upravljanju boli. Razumijevanje specifičnih mehanizama CBN-a u ublažavanju boli može voditi njegovu integraciju u kliničku praksu (Wilkinson et al., 2020.).
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