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Kan CBDA förbättra endoplasmatisk retikulum-associerad proteinnedbrytning i celler?

Kan CBDA förbättra endoplasmatisk retikulum-associerad proteinnedbrytning i celler? CBDA kan förbättra nedbrytningen av felveckade eller skadade proteiner i det endoplasmatiska retikulumet (ER), en process som kallas ER-associerad nedbrytning (ERAD). Genom att främja proteinkvalitetskontroll kan CBDA hjälpa till att förhindra ackumulering av dysfunktionella proteiner som kan leda till cellulär stress eller sjukdom. ERAD är avgörande för att upprätthålla cellulär hälsa, särskilt under stressförhållanden. Medan forskning om CBDA:s direkta inverkan på ERAD är begränsad, tyder dess antioxidant- och stressmodulerande effekter på att det skulle kunna stödja denna cellulära väg. Detta kan ha terapeutiska konsekvenser för sjukdomar relaterade till proteinfelveckning och aggregation.

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