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How do endocannabinoids influence the body’s pain perception through the Endocannabinoid System?

How do endocannabinoids influence the body’s pain perception through the Endocannabinoid System? Endocannabinoids influence the body’s pain perception by interacting with CB1 and CB2 receptors in the nervous system and immune system. When endocannabinoids bind to these receptors, they help reduce the transmission of pain signals, providing analgesic effects. The ECS also modulates the release of neurotransmitters involved in pain sensation, such as glutamate and substance P, reducing the overall sensation of pain. Additionally, endocannabinoids help regulate inflammation, which is often a source of pain. Together, these mechanisms enable the body to manage and alleviate pain more effectively.
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