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How does the phase state (e.g., solid, liquid, gel) of cannabinoids in patches affect their release and absorption rate through the skin?

How does the phase state (e.g., solid, liquid, gel) of cannabinoids in patches affect their release and absorption rate through the skin? The phase state of cannabinoids in patches significantly influences their release and absorption rate. Solid formulations may release cannabinoids more slowly, while liquid or gel-based formulations can facilitate faster release and absorption due to their higher mobility and lower viscosity. Gel-based patches, for example, offer a balance by providing a sustained release while maintaining high cannabinoid solubility. The choice of phase state is crucial for tailoring the patch’s release profile to meet specific therapeutic needs, such as rapid pain relief or prolonged effects.

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