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Kakav je odnos između snage kanabinoida i internalizacije CB1 receptora tijekom psihoaktivnih odgovora?

Kakav je odnos između snage kanabinoida i internalizacije CB1 receptora tijekom psihoaktivnih odgovora? Snaga kanabinoida poput THC-a utječe na internalizaciju CB1 receptora određujući koliko se snažno kanabinoidi vežu na te receptore. Visokopotentni kanabinoidi uzrokuju veću aktivaciju receptora, što dovodi do izraženije internalizacije, što smanjuje dostupnost receptora za buduću signalizaciju. Ovaj proces internalizacije je oblik desenzibilizacije, smanjujući ukupnu reakciju ECS-a na naknadno izlaganje kanabinoidima. Kako se snaga kanabinoida povećava, obično dolazi do povećanja regulacije receptora i razvoja tolerancije, što zahtijeva veće doze za isti psihoaktivni učinak. Ovaj odnos igra značajnu ulogu u toleranciji i ukupnom trajanju i intenzitetu psihoaktivnog iskustva.

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