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Koje su razlike u učincima THC-a na muškarce i žene zbog hormonalnih ili fizioloških varijacija?

Koje su razlike u učincima THC-a na muškarce i žene zbog hormonalnih ili fizioloških varijacija? Učinci THC-a na muškarce i žene razlikuju se zbog hormonalnih varijacija, posebice estrogena, koji modulira osjetljivost CB1 receptora. Žene mogu doživjeti jače psihoaktivne učinke zbog viših razina estrogena, koji povećavaju afinitet THC-a za ove receptore, osobito tijekom određenih faza menstrualnog ciklusa. Osim toga, sastav tjelesne masti utječe na skladištenje i oslobađanje THC-a, što može varirati između muškaraca i žena. Žene također imaju tendenciju doživjeti veća kognitivna oštećenja s korištenjem THC-a od muškaraca, vjerojatno zbog rodno specifičnih regija mozga koje su osjetljivije na spoj. Ove razlike sugeriraju da spolni hormoni igraju značajnu ulogu u farmakodinamici i subjektivnim učincima THC-a.

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