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In che modo i cannabinoidi contenuti nei cerotti transdermici influiscono sulla circolazione e sul rilascio di nutrienti o altri farmaci alla pelle?

In che modo i cannabinoidi contenuti nei cerotti transdermici influiscono sulla circolazione e sul rilascio di nutrienti o altri farmaci alla pelle? I cannabinoidi influenzano la vasodilatazione locale, che può migliorare l’apporto di nutrienti e ossigeno ai tessuti cutanei. L’aumento del flusso sanguigno può migliorare l’assorbimento transdermico ma potrebbe anche alterare la distribuzione dei farmaci co-somministrati. L’interazione con i vasi sanguigni cutanei può aiutare a modulare l’infiammazione e i processi di riparazione della pelle. È necessaria un’attenta formulazione per prevenire interazioni farmacologiche indesiderate quando si utilizzano cerotti ai cannabinoidi con altri trattamenti topici (Giacoppo et al., 2014).

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