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In che modo l'interazione tra delta-9-tetraidrocannabinolo (THC) e cannabidiolo (CBD) influenza l'attività dei recettori CB1?

In che modo l'interazione tra delta-9-tetraidrocannabinolo (THC) e cannabidiolo (CBD) influenza l'attività dei recettori CB1? THC e CBD interagiscono sui recettori CB1, ma in modi opposti. Il THC agisce come un agonista parziale dei recettori CB1, producendo effetti psicoattivi, mentre il CBD ha un ruolo più modulatorio e può agire come modulatore allosterico negativo dell'attività dei recettori CB1. Ciò significa che il CBD può ridurre l’affinità di legame del THC con i recettori CB1, smorzando potenzialmente gli effetti psicoattivi del THC. Insieme, l’interazione del THC e del CBD può alterare l’intensità e la durata degli effetti del THC, con il CBD che modera il potenziale di effetti avversi come ansia e paranoia.

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