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How do CBD and THC work synergistically to modulate pain perception in patients with fibromyalgia and chronic pain syndromes?

How do CBD and THC work synergistically to modulate pain perception in patients with fibromyalgia and chronic pain syndromes? CBD and THC modulate pain perception by activating CB1 and CB2 receptors in the central and peripheral nervous systems. THC provides immediate analgesic effects by binding to CB1 receptors, while CBD modulates inflammation and pain signaling through both receptor-dependent and independent mechanisms. Their combined action reduces pain intensity and improves the overall pain threshold. Additionally, CBD enhances THC’s analgesic effects by minimizing its psychoactive impact. Together, they provide a more effective and tolerable treatment for fibromyalgia and other chronic pain conditions.
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