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How do endocannabinoids influence the body’s response to stress through the Endocannabinoid System?

How do endocannabinoids influence the body’s response to stress through the Endocannabinoid System? Endocannabinoids play a critical role in the body’s response to stress by regulating the release of stress hormones and maintaining emotional balance. Through the Endocannabinoid System, endocannabinoids like anandamide and 2-AG bind to CB1 and CB2 receptors in the brain and peripheral tissues. This helps modulate the activation of the hypothalamic-pituitary-adrenal (HPA) axis, which is responsible for stress hormone release. Endocannabinoids also influence mood, anxiety, and fear responses, promoting relaxation and reducing stress-induced inflammation. Together, they help the body adapt to stress and maintain emotional equilibrium.
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