How do THC's effects vary between individuals based on genetic factors and prior cannabis use?
How do THC's effects vary between individuals based on genetic factors and prior cannabis use? THC's effects can vary significantly between individuals based on genetic factors, such as cannabinoid receptor polymorphisms, and prior cannabis use history. Genetic variations in cannabinoid receptors can influence an individual's sensitivity to THC, resulting in differing psychoactive experiences and therapeutic responses. Additionally, prior cannabis use can lead to tolerance, where individuals require higher doses to achieve similar effects, or sensitization, where certain effects become amplified over time. This variability necessitates personalized dosing strategies and careful monitoring for patients using THC therapeutically. Understanding these factors is crucial for healthcare providers to optimize treatment plans and mitigate potential adverse effects (Choi et al., 2019).