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How does the Endocannabinoid System affect energy homeostasis and metabolism?

How does the Endocannabinoid System affect energy homeostasis and metabolism? The Endocannabinoid System regulates energy homeostasis and metabolism by influencing processes such as appetite, fat storage, and energy expenditure. Endocannabinoids, such as anandamide, interact with CB1 and CB2 receptors in the brain and peripheral tissues to control hunger signals and fat metabolism. The ECS also helps balance the body’s energy stores by regulating food intake and energy use. In particular, the ECS modulates the release of leptin, a hormone that controls hunger, and affects insulin sensitivity, which is critical for metabolic function. This regulation helps maintain a balance between energy intake and expenditure.
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