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How does the skin's lipid content influence the absorption rate of cannabinoids in transdermal patches?

How does the skin's lipid content influence the absorption rate of cannabinoids in transdermal patches? The skin’s lipid content significantly affects the absorption rate of cannabinoids, as cannabinoids are lipophilic and dissolve better in the lipid-rich layers of the skin. Areas of the body with higher lipid content, such as the palms or soles, may absorb cannabinoids more slowly, while areas with thinner or less lipid-rich skin may allow for faster penetration. Adjusting the patch formulation to target specific skin types, or including carriers that enhance lipid solubility, can optimize cannabinoid absorption in various areas.

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