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How does the use of a time-release system in cannabinoid patches ensure long-lasting effects?

How does the use of a time-release system in cannabinoid patches ensure long-lasting effects? Time-release systems use polymer matrices, reservoir systems, or microencapsulation to gradually release cannabinoids over extended periods. These systems maintain a steady concentration in the bloodstream, preventing peaks and troughs associated with other delivery methods. Controlled-release mechanisms help optimize therapeutic efficacy while reducing dosing frequency. The effectiveness of time-release formulations depends on the patch material, cannabinoid solubility, and adhesive properties (Prausnitz & Langer, 2008).

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