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What is the role of transdermal permeation enhancers in cannabinoid patch formulations?

What is the role of transdermal permeation enhancers in cannabinoid patch formulations? Transdermal permeation enhancers are compounds that facilitate the absorption of cannabinoids through the skin by temporarily altering the skin’s barrier function. These enhancers can increase the skin's permeability to cannabinoids, allowing for more efficient absorption into the bloodstream. Common enhancers include alcohols, fatty acids, and surfactants that break down the skin's lipid layers, making it easier for cannabinoids to penetrate. By optimizing the use of permeation enhancers, manufacturers can improve the efficacy of cannabinoid patches, especially for those cannabinoids with low natural skin permeability.

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