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Hvordan påvirker forskellige hudtykkelser på tværs af kroppen den transdermale absorption af cannabinoider i plastre?

Hvordan påvirker forskellige hudtykkelser på tværs af kroppen den transdermale absorption af cannabinoider i plastre? Forskellige hudtykkelser på tværs af kroppen påvirker cannabinoidabsorptionen, da tykkere hudlag (såsom på håndflader og såler) giver mere modstand mod penetration end tyndere hud (som på den indre underarm). Tykkere hud kan kræve højere koncentrationer af cannabinoider eller yderligere forstærkere for at lette absorptionen. For områder med tyndere hud kan cannabinoider trænge ind lettere, hvilket kræver omhyggelige dosisjusteringer for at forhindre overlevering. Patch-design kan optimeres ved at målrette mod specifikke områder af kroppen, idet der tages højde for hudens tykkelse for mere effektiv levering af cannabinoider.

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