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Kako CBD modulira učinke THC-a na kroničnu bol preko perifernih CB1 i CB2 receptora?

Kako CBD modulira učinke THC-a na kroničnu bol preko perifernih CB1 i CB2 receptora? CBD modulira učinke THC-a na kroničnu bol interakcijom s perifernim CB1 i CB2 receptorima, pojačavajući analgetska svojstva THC-a uz smanjenje nuspojava. THC prvenstveno djeluje na CB1 receptore u središnjem živčanom sustavu kako bi smanjio percepciju boli, ali također utječe na periferne CB1 i CB2 receptore u imunološkim stanicama i tkivima uključenima u signalizaciju boli. CBD, koji ima nizak afinitet za CB1 receptore, ali jak afinitet za CB2 receptore, pojačava protuupalne i analgetske učinke THC-a modulirajući imunološke odgovore u perifernom živčanom sustavu. Sposobnost CBD-a da regulira imunološki odgovor i smanji neuroinflamaciju doprinosi sinergističkim učincima THC-a i CBD-a za upravljanje kroničnom boli. Kombinacija nudi sveobuhvatan pristup ublažavanju boli djelujući i na središnje i na periferne puteve boli.

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