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Kako se endokanabinoidni sustav prilagođava opetovanoj stimulaciji psihoaktivnim kanabinoidima?

Kako se endokanabinoidni sustav prilagođava opetovanoj stimulaciji psihoaktivnim kanabinoidima? Endokanabinoidni sustav (ECS) prilagođava se ponovljenoj stimulaciji snižavanjem CB1 receptora i mijenjanjem endokanabinoidnog tonusa tijekom vremena. To dovodi do smanjene osjetljivosti na THC, zbog čega su pojedincima potrebne veće doze za iste psihoaktivne učinke. Kronična uporaba također može dovesti do promjena u aktivnosti endokanabinoidnih enzima, utječući na to kako tijelo prerađuje kanabinoide. ECS također može biti podvrgnut desenzibilizaciji receptora, što znači da će kanabinoidi imati smanjeni učinak pri istim koncentracijama. Ovaj proces pridonosi razvoju tolerancije i može zahtijevati povremene stanke ili prilagodbe doze kako bi se održali terapijski ili psihoaktivni učinci.

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