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Kako THC i CBD međusobno djeluju kako bi modulirali proizvodnju citokina u perifernim tkivima?

Kako THC i CBD međusobno djeluju kako bi modulirali proizvodnju citokina u perifernim tkivima? THC i CBD različito djeluju na imunološki sustav, utječući na proizvodnju citokina u perifernim tkivima. THC prvenstveno aktivira CB1 i CB2 receptore na imunološkim stanicama, potencijalno dovodeći do imunosupresivnih učinaka i povećanog oslobađanja citokina u određenim upalnim stanjima. CBD, nasuprot tome, može modulirati aktivnost imunoloških stanica interakcijom s CB2 receptorima, smanjujući proizvodnju proupalnih citokina i povećavajući imunološku toleranciju. Kada se koriste zajedno, THC i CBD mogu pružiti uravnotežen pristup regulaciji imunoloških odgovora, pri čemu CBD smanjuje upalu, a THC potencijalno pojačava analgeziju u stanjima kao što su autoimune bolesti. Ova kombinacija bi mogla biti korisna za upravljanje kroničnom upalom i imunološkim poremećajima.

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