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Kakvi su učinci kombinacije THC-a i CBD-a na dugotrajnu sinaptičku potencijaciju?

Kakvi su učinci kombinacije THC-a i CBD-a na dugotrajnu sinaptičku potencijaciju? Kombinacija THC-a i CBD-a može utjecati na dugoročno sinaptičko potenciranje (LTP), ključni mehanizam neuroplastičnosti i formiranja pamćenja. THC može inducirati LTP u određenim regijama mozga poput hipokampusa, potičući kodiranje pamćenja i učenje. Međutim, u visokim dozama, THC može oslabiti LTP, što dovodi do kognitivne disfunkcije. CBD, modulirajući aktivnost CB1 receptora i smanjujući neuroinflamaciju, može očuvati LTP i promicati sinaptičko preoblikovanje, povećavajući neuroplastičnost. Zajedno, THC i CBD mogu imati sinergistički učinak na LTP, pružajući kognitivne prednosti, a istovremeno smanjujući negativan utjecaj THC-a na funkciju pamćenja.

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