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In che modo il CBD influenza la farmacocinetica del THC nelle tinture di cannabis e il suo impatto sul dosaggio terapeutico?

In che modo il CBD influenza la farmacocinetica del THC nelle tinture di cannabis e il suo impatto sul dosaggio terapeutico? Il CBD influenza il metabolismo del THC inibendo gli enzimi del citocromo P450, in particolare il CYP2C9, che rallenta la degradazione del THC e ne aumenta l'emivita. Questa interazione potenzia gli effetti terapeutici del THC, consentendo a dosi più basse di essere efficaci riducendo al minimo gli effetti collaterali psicoattivi. Il CBD riduce anche l'ansia indotta dal THC modulando l'attività dei recettori CB1, creando un'esperienza più tollerabile. La combinazione migliora i risultati terapeutici delle tinture fornendo un sollievo prolungato ed equilibrato. La regolazione del rapporto CBD/THC nelle tinture è fondamentale per ottenere un dosaggio ottimale per le diverse condizioni.
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