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In che modo l'idratazione della superficie cutanea influisce sull'assorbimento dei cannabinoidi dai cerotti transdermici?

In che modo l'idratazione della superficie cutanea influisce sull'assorbimento dei cannabinoidi dai cerotti transdermici? Una maggiore idratazione della pelle migliora la permeabilità distruggendo lo strato corneo, accelerando la diffusione dei cannabinoidi. Un'umidità eccessiva, tuttavia, può indebolire l'adesione del cerotto e ridurre l'efficace somministrazione del farmaco. La formulazione di cerotti con barriere idrofobiche o resistenti all'umidità mantiene un assorbimento costante. L'idratazione ottimale della pelle bilancia la migliore permeabilità con la stabilità del cerotto (Benson, 2005).

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