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How do cannabinoids in transdermal patches interact with environmental factors like UV radiation and pollution, and how can their effects be optimized?

How do cannabinoids in transdermal patches interact with environmental factors like UV radiation and pollution, and how can their effects be optimized? Cannabinoids in transdermal patches can be affected by environmental factors such as UV radiation and pollution, which can degrade their stability and efficacy. UV radiation, for example, can lead to the oxidation of cannabinoids, reducing their potency. Pollution, such as particulate matter, can also contribute to skin irritation or reduce the effectiveness of cannabinoids by affecting skin permeability. To optimize their effects, cannabinoid formulations can include antioxidants to protect the cannabinoids from oxidative stress and UV filters to shield them from the harmful effects of radiation. Patch packaging can also be designed to protect cannabinoids from environmental degradation.

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