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How do CBD and THC affect neuroinflammation through the inhibition of NF-kB and other inflammatory pathways in brain disorders?

How do CBD and THC affect neuroinflammation through the inhibition of NF-kB and other inflammatory pathways in brain disorders? CBD and THC inhibit the NF-kB pathway, a key driver of neuroinflammation, by reducing pro-inflammatory cytokine production. CBD also interacts with PPAR-gamma receptors, amplifying its anti-inflammatory effects. THC’s activation of CB1 receptors reduces neuronal hyperexcitability, complementing CBD’s action. This combination protects against neuroinflammation in conditions like Alzheimer’s and multiple sclerosis. Their synergistic effects promote brain health and reduce disease progression.
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