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How does the use of transdermal cannabinoid patches impact the bioavailability of cannabinoids compared to sublingual or oral methods?

How does the use of transdermal cannabinoid patches impact the bioavailability of cannabinoids compared to sublingual or oral methods? Transdermal cannabinoid patches typically offer higher bioavailability compared to oral or sublingual methods because they bypass the digestive system and first-pass metabolism in the liver. This direct absorption into the bloodstream ensures that a greater percentage of cannabinoids, such as CBD and CBG, reach their target tissues. Oral and sublingual methods are subject to enzymatic breakdown in the digestive tract, reducing the amount of cannabinoids that enter circulation. Transdermal delivery provides more consistent and efficient delivery, leading to potentially more reliable therapeutic effects.

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