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Hoe kunnen terpenen in cannabinoïdepleisters de opname van cannabinoïden door de huid verbeteren of veranderen?

Hoe kunnen terpenen in cannabinoïdepleisters de opname van cannabinoïden door de huid verbeteren of veranderen? Terpenen kunnen de opname van cannabinoïden verbeteren door te werken als natuurlijke penetratieversterkers, waardoor de huidbarrière wordt verstoord en de doorlaatbaarheid wordt verbeterd. Bepaalde terpenen, zoals limoneen en myrceen, hebben lipofiele eigenschappen waardoor cannabinoïden gemakkelijker door de huidlagen kunnen diffunderen. Ze kunnen ook de biologische beschikbaarheid van cannabinoïden wijzigen door interactie met huidenzymen en de lokale bloedstroom te veranderen. Deze synergie kan de werkzaamheid van transdermale cannabinoïdepleisters verbeteren, waardoor betere systemische of plaatselijke effecten mogelijk zijn.

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