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Kakav je učinak CBD-a na THC-inducirane promjene u neuronskoj ekscitabilnosti?

Kakav je učinak CBD-a na THC-inducirane promjene u neuronskoj ekscitabilnosti? Pokazalo se da CBD modulira promjene u neuronskoj ekscitabilnosti izazvane THC-om, uglavnom tako što se suprotstavlja THC-ovoj pretjeranoj stimulaciji CB1 receptora. THC može povećati neuronsku ekscitabilnost, što dovodi do učinaka poput kognitivnog oštećenja i psihoaktivnih poremećaja. CBD, djelujući kao modulator endokanabinoidnog sustava i ionskih kanala kao što je TRPV1, smanjuje prekomjerno aktiviranje neurona i stabilizira ekscitabilnost. Ovaj učinak može pomoći u sprječavanju negativnih kognitivnih i psihijatrijskih nuspojava THC-a, kao što su tjeskoba i halucinacije, dok održava terapeutske učinke poput analgezije. Moduliranjem neuronske ekscitabilnosti, CBD može učiniti upotrebu THC-a sigurnijom i učinkovitijom, posebno u terapeutskim kontekstima koji zahtijevaju preciznu modulaciju aktivnosti mozga.

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