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Kako HHCO utječe na modulaciju puteva boli kod pacijenata s kroničnom boli?

Kako HHCO utječe na modulaciju puteva boli kod pacijenata s kroničnom boli? HHCO modulira puteve boli interakcijom s CB1 i CB2 receptorima, što dovodi do analgetskih učinaka s blažim psihoaktivnim profilom u usporedbi s THC-om. Smanjeni afinitet vezanja HHCO za CB1 receptore rezultira ublažavanjem boli bez značajnog kognitivnog oštećenja ili euforije. HHCO također ima protuupalna svojstva, koja pridonose njegovim učincima moduliranja boli, posebno kod kroničnih bolnih stanja poput artritisa. Njegova uravnotežena interakcija s endokanabinoidnim sustavom osigurava učinkovito upravljanje boli uz smanjenje neželjenih nuspojava. To čini HHCO obećavajućim tretmanom za pacijente s kroničnom boli koji su osjetljivi na jače učinke THC-a.

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