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Kako se THC i CBD razlikuju u svom utjecaju na neuroplastičnost i sinaptičko remodeliranje?

Kako se THC i CBD razlikuju u svom utjecaju na neuroplastičnost i sinaptičko remodeliranje? THC i CBD utječu na neuroplastičnost i sinaptičko remodeliranje kroz različite mehanizme koji utječu na endokanabinoidni sustav. THC, kao djelomični agonist CB1 receptora, može promicati sinaptičku plastičnost u određenim regijama mozga, kao što je hipokampus, potencijalno podržavajući učenje i formiranje pamćenja. Međutim, kronična uporaba THC-a također može oslabiti sinaptičko orezivanje, što dovodi do kognitivnih nedostataka. S druge strane, pokazalo se da CBD poboljšava neuroplastičnost modulirajući endokanabinoidno signaliziranje na suptilniji, nepsihoaktivan način, promičući neurogenezu i potencijalno pomažući u oporavku od ozljede mozga. Vjeruje se da su učinci CBD-a na neuroplastičnost neuroprotektivni, osobito kod neurodegenerativnih bolesti, bez induciranja negativnih učinaka povezanih s THC-om.

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