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Kako specifične varijante CB1 receptora utječu na psihoaktivne učinke kanabinoida u različitim populacijama?

Kako specifične varijante CB1 receptora utječu na psihoaktivne učinke kanabinoida u različitim populacijama? Varijacije u genu CNR1, koji kodira receptor CB1, mogu dovesti do razlika u gustoći ili funkciji receptora, utječući na to kako pojedinci reagiraju na kanabinoide. Na primjer, neki ljudi mogu imati genetske varijante koje njihove CB1 receptore čine osjetljivijima na THC, što dovodi do jačih psihoaktivnih učinaka. Nasuprot tome, pojedinci s drugim varijantama mogu doživjeti blaže učinke zbog smanjenog vezanja na receptore. Ove genetske razlike mogu utjecati na toleranciju, psihoaktivnu osjetljivost i terapeutski potencijal kanabinoida. Dakle, genetska raznolikost igra ulogu u tome kako THC i drugi kanabinoidi utječu na pojedince u različitim populacijama.

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