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Kako THC i CBD međusobno djeluju kako bi modulirali cirkadijalni ritam i arhitekturu spavanja?

Kako THC i CBD međusobno djeluju kako bi modulirali cirkadijalni ritam i arhitekturu spavanja? THC i CBD imaju različite uloge u modulaciji cirkadijalnih ritmova i arhitekture spavanja. THC može potaknuti san djelujući kao agonist CB1 receptora, potičući sedaciju i produbljujući duboki san (sporovalno spavanje). Međutim, u visokim dozama, THC može poremetiti REM spavanje, što dovodi do smanjenja ciklusa snova. Nasuprot tome, pokazalo se da CBD normalizira obrasce spavanja utječući na receptore serotonina i adenozina, koji su uključeni u regulaciju ciklusa spavanja i budnosti. CBD može poboljšati kontinuitet sna i smanjiti poremećaje spavanja uzrokovane THC-om. Kombinacija THC-a i CBD-a stoga može ponuditi uravnoteženost

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