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Kako THC i CBD međusobno djeluju kako bi utjecali na epigenetske promjene u moždanim stanicama?

Kako THC i CBD međusobno djeluju kako bi utjecali na epigenetske promjene u moždanim stanicama? THC i CBD u interakciji s epigenomom utječu na ekspresiju gena u moždanim stanicama, ali njihovi se učinci razlikuju. THC prvenstveno utječe na signalizaciju posredovanu CB1 receptorom, što može dovesti do promjena u modifikacijama histona i obrascima metilacije DNK, potencijalno utječući na gene povezane s pamćenjem, odgovorom na stres i sinaptičkom plastičnošću. S druge strane, pokazalo se da CBD utječe na epigenetsku regulaciju svojim utjecajem na CB2 receptore i TRPV1 receptore, što dovodi do promjena u ekspresiji gena povezanih s neuroinflamacijom, neuroprotekcijom i neurogenezom. Kombinacija THC-a i CBD-a može stvoriti jedinstveni epigenetski profil koji utječe na različite funkcije mozga, od kognitivnih performansi do emocionalne regulacije. Ova epigenetska modulacija mogla bi imati značajne implikacije na dugoročno zdravlje mozga i razvoj neuroloških poremećaja.

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