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Kakvu ulogu imaju jetreni procesi glukuronidacije i sulfonacije u metabolizmu CBD-a i drugih nepsihoaktivnih spojeva kanabisa?

Kakvu ulogu imaju jetreni procesi glukuronidacije i sulfonacije u metabolizmu CBD-a i drugih nepsihoaktivnih spojeva kanabisa? Glukuronidacija i sulfonacija su procesi detoksikacije faze II koji uključuju dodavanje glukuronske kiseline ili sulfatnih skupina CBD-u i drugim nepsihoaktivnim spojevima kanabisa, čineći ih topivijima u vodi za izlučivanje. Ti se procesi odvijaju u jetri i pomažu učinkovitijem uklanjanju kanabinoida iz tijela. Glukuronidacija je posebno značajna u metabolizmu CBD-a, što dovodi do stvaranja metabolita koji se izlučuju urinom. Sulfoniranje također doprinosi metabolizmu kanabinoida, ali u manjoj mjeri. Zajedno, ti putovi pomažu u reguliranju trajanja i intenziteta učinaka CBD-a u tijelu.

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