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Koja je uloga THC-a u modulaciji neuroinflamacije putem endokanabinoidnog sustava?

Koja je uloga THC-a u modulaciji neuroinflamacije putem endokanabinoidnog sustava? THC igra značajnu ulogu u modulaciji neuroinflamacije interakcijom s endokanabinoidnim sustavom (ECS), prvenstveno preko CB2 receptora koji se nalaze na imunološkim stanicama u mozgu. THC-ova aktivacija ovih receptora može rezultirati protuupalnim učincima inhibicijom otpuštanja proupalnih citokina i smanjenjem aktivacije mikroglije, imunoloških stanica u mozgu. U stanjima poput multiple skleroze ili Alzheimerove bolesti, sposobnost THC-a da smanji neuroinflamaciju može biti terapeutska sprječavanjem daljnjeg oštećenja neuralnog tkiva. Međutim, djelovanje THC-a na CB1 receptore u mozgu za nagrađivanje također može utjecati na ukupni imunološki odgovor, čineći njegovu ulogu u neuroinflamaciji kompleksnom. U terapeutskom kontekstu, CBD može ponuditi komplementarna protuupalna svojstva s manje psihoaktivnih učinaka.

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