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Koje su neuroadaptivne promjene uzrokovane kroničnom upotrebom THC-a u mozgu?

Koje su neuroadaptivne promjene uzrokovane kroničnom upotrebom THC-a u mozgu? Kronična uporaba THC-a dovodi do smanjenja regulacije CB1 receptora i promjene neuroplastičnosti u regijama mozga poput hipokampusa i prefrontalnog korteksa. Ova prilagodba smanjuje osjetljivost endokanabinoidnog sustava, pridonoseći toleranciji i smanjenim psihoaktivnim učincima tijekom vremena. Produljena izloženost također može oslabiti kognitivnu funkciju, utječući na procese poput donošenja odluka i vraćanja pamćenja. Osim toga, kronična uporaba može uzrokovati promjene u dopaminergičkoj signalizaciji, utječući na sustave nagrađivanja. Ove neuroadaptivne promjene mogu utjecati na regulaciju raspoloženja i povećati osjetljivost na kognitivni pad uz kontinuiranu upotrebu.

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