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Koji su kombinirani učinci THC-a i CBD-a na aktivaciju TRPV2 receptora?

Koji su kombinirani učinci THC-a i CBD-a na aktivaciju TRPV2 receptora? THC i CBD stupaju u interakciju s TRPV2 receptorom, ali imaju različite uloge u njegovoj aktivaciji. THC nastoji aktivirati TRPV2 receptore neizravno putem CB1 receptorske signalizacije, što može dovesti do povećane neuronske aktivnosti i modulacije boli. CBD, s druge strane, može modulirati aktivnost TRPV2 receptora djelujući kao modulator priljeva kalcija kroz ovaj receptor, potencijalno pridonoseći neuroprotektivnim učincima. Kada se koriste zajedno, THC i CBD mogu sinergistički utjecati na aktivaciju TRPV2, pri čemu THC ublažava bol, a CBD potencijalno djeluje protiv ekscitotoksičnosti. Ova kombinacija može imati terapijski potencijal u liječenju boli i neurodegenerativnih stanja.

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