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How can clinical trials be designed to effectively assess the long-term safety of cannabinoid therapies?

How can clinical trials be designed to effectively assess the long-term safety of cannabinoid therapies? Designing clinical trials to effectively assess the long-term safety of cannabinoid therapies requires careful consideration of study design, participant selection, and outcome measures. Utilizing a randomized, controlled design with adequate sample sizes can enhance the reliability of findings regarding safety. Longitudinal follow-up is crucial for capturing long-term adverse effects and assessing the durability of therapeutic benefits. Including diverse populations in clinical trials can help identify potential safety concerns specific to different demographic groups. Additionally, employing comprehensive safety monitoring protocols and standardized reporting of adverse events can facilitate thorough assessments of cannabinoid therapies' long-term safety profiles (Calkins et al., 2020).
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