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How can the release rate of cannabinoids in a patch be controlled by factors like temperature, skin friction, or movement?

How can the release rate of cannabinoids in a patch be controlled by factors like temperature, skin friction, or movement? The release rate of cannabinoids in a patch can be controlled by using thermosensitive, pressure-sensitive, or friction-responsive materials that alter the rate of cannabinoid diffusion based on environmental factors. For example, increased temperature from body heat or exercise can trigger faster release, while friction from skin movement can enhance the absorption rate. Patch formulations can also include layers that respond to physical activity, releasing cannabinoids more rapidly when required. These dynamic systems help align cannabinoid delivery with the user’s needs.

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